Pharmacological modulation of visceral tone: documented and potential sensory effects
| Reduced sensation or increased pain threshold to | |||
|---|---|---|---|
| Agent | Action | Volume distension | Pressure distension |
| Atropine51 52 | ↓Colonic tone | ? | ? |
| CCK51 | No effect on tone | ? | ? |
| 5-HT3 antagonists | |||
| OND53 54 | ↓Colonic tone pm | + | ? |
| GRA48 | No change in compliance | + | ? |
| ALO46 | ↓Colonic tone,↑compliance | + | ? |
| 5-HT1 agonists49 55 | ↓Colonic and gastric fasting, and pm tone | + | ? |
| Octreotide40-45 | ↓Colonic pm tone,↑phasic contractions | + | ?/+ |
| α2Agonist20 26 | ↓Colonic tone,↑compliance | ? | + |
| Fedotozine50 | No change in compliance | + | + |
| Cisapride47 | ↓Gastric tone pm. ?↓compliance | − | − |
pm, post meal; CCK, cholecystokinin; OND, ondansetron; GRA, granisetron; ALO, alosetron.
?, unknown; +, reduced sensation; −, increased sensation