Table 1

Clinical, histopathological data, and comparative genomic hybridisation (CGH) findings of the 26 sporadic neuroendocrine gastroenteropancreatic tumours and six adenocarcinomas

Case1-a Sex/age Histology Primary Metastases Functionality CGH gains CGH losses
1 M/43NETForegut (pancreas,1-bgastrinoma)Liver+15; 16p; 17p; 20qNone
2 M/34NETForegut (pancreas, insulinoma)No+4; 5; 11; 12; 15; 18p; 18q; 19; 20; 219q; 22
3 F/15NETForegut (duodenum/jejunum, gastrinoma) Liver, lymphnodes+None3p; 20p
4 M/52NETForegut (pancreas, gastrinoma)Liver+2q; 12; 143; 5q
5 F/69NETForegut (pancreas)Liver+4; 5; 7; 9; 12; 13; 14; 16p; 17; 18; 19; 20; 21q; 221p; 2p; 2q; 3; 6q; 8q
6F/67NETForegut (pancreas, insulinoma)No+3p; 5q; 7; 10p; 15q; 17p; 19; 20q2q; 4q; 12q; 13q
7M/53NETForegut (pancreas, insulinoma)No+8q; 9p; 9q; 10q; 13q; 15q; 21q1p; 1q; 2q; 6q
8 M/65NETForegut (bronchial system) Liver, pleura+4; 7; 9; 16; 19; 20q; 22q1p; 2q; 11p; 11q; 12p; 13q; 14q
9 M/49NETForegut (pancreas) Liver, lymphnodes4; 5; 7; 9p; 12; 13; 14; 17; 18; 19; 201p
10 F/65NETForegut (duodenum)No10p; 11q; 16p; 17p; 17q; 19; 20q; 2218q
11M/60NETForegut (pancreas)Liver, lung2p; 10q; 20p1p; 1q; 4q; 6q; 11; 18
12F/37NETForegut (pancreas) Liver 1q; 8q; 11p; 11q; 12p; 12q; 14q; 17p; 17q; 18q; 20p2q; 4q; 6p; 7q; 10p
13F/64NETMidgut (ileum)Liver,ovary +4; 5; 7; 9q; 10q; 14q; 17p; 17q; 1911q
14M/72NETMidgut (ileum) Liver, lymphnodes+4; 5; 7; 14; 17q; 20;2q; 3q; 9; 13q; 18
15 M/68NETMidgut (ileum)Liver, lymphnodes+4; 8q; 10p; 10q; 11q; 16p; 17q; 19; 20; 22q1p; 2p; 2q; 3p; 6q; 9p; 11p; 18q
16 M/62NETMidgut (ileocecal valve)Liver, lymphnodes+None18p
17 M/59NETMidgut (caecum) Lymph nodes +4; 10q; 14; 17q; 19p; 19q; 2018
18 F/72NETMidgut (ileocecal valve)Liver+4; 5; 17q; 20qNone
19F/54NETMidgut (ileum)Liver+4; 5; 13q; 14q; 20q8p; 16p; 17; 19; 22
20 F/57NETMidgut (ileum) Liver +4q; 5p; 5q; 10; 12q; 17p; 19q8p; 11q; 12p; 13; 18
21M/55NETMidgut (ileum)Liver+17q; 19; 22qNone
22M/65NETMidgut (ileum) Liver +19; 22q3; 9; 18
23 F/59NETMidgut (ileocecal valve) Liver +17q; 19p18
24 M/69NETMidgut (jejunum) Liver 17q; 19pNone
25M/58NETMidgut (ileum)NoNoneNone
26 M/65NETMidgut (ileum) Liver 1p; 16p; 19; 22None
  • 1-a CGH analysis was performed with reference DNA of peripheral blood lymphocytes of patients in bold type.

  • 1-b CGH analysis was performed on tissue samples highlighted in bold.