Affected sibling pairs from hereditary pancreatitis kindreds
| Trypsin mutation | Type of relationship | Age of onset of phenotype (y) | Difference in age of onset (y) |
| + R122H | S | 2, 3 | 1 |
| + R122H | S | 2, 3 | 1 |
| + R122H | S | 3, 3 | 0 |
| + R122H | S | 2, 3 | 1 |
| + N29I | S | 9, 6 | 3 |
| Other | S | 4, 6 | 2 |
| + N29I | S | 28, 40 | 12 |
| + R122H | S | 18, 21 | 3 |
| + R122H | S | 21, 19 | 2 |
| + R122H | S | 18, 19 | 1 |
| + R122H | S | 13, 13 | 0 |
| Other | S | 12, 9 | 3 |
| Other | S | 2, 4 | 2 |
| + R122H | S | 18, 15 | 3 |
| Other | S | 6, 8 | 2 |
| + R122H | S | 15, 14 | 1 |
| + Other | S | 20, 20 | 0 |
| + R122H | S | 3, 7 | 4 |
| + R122H | S | 7, 5 | 2 |
| + R122H | S | 3, 5 | 2 |
| + R122H | S | 5, 11 | 6 |
| + R122H | S | 16, 11 | 5 |
| + R122H | B | 26, 20 | 6 |
| + Other | B | 22, 19 | 3 |
| + Other | B | 20, 20 | 0 |
| + Other | B | 19, 15 | 4 |
| + R122H | B | 11, 3 | 8 |
| + R122H | S/B | 2, 1 | 1 |
| + R122H | S/B | 3, 1 | 2 |
| + R122H | S/B | 3, 1 | 2 |
| + R122H | S/B | 38, 17 | 21 |
| + R122H | S/B | 12, 10 | 2 |
| + Other | S/B | 13, 14 | 1 |
| + Other | S/B | 2, 2 | 0 |
| + R122H | S/B | 10, 11 | 1 |
| +N29I | S/B | 2, 12 | 10 |
| + R122H | S/B | 35, 6 | 29 |
| + Other | S/B | 18, 21 | 3 |
| + R122H | S/B | 3, 4 | 1 |
| + R122H | S/B | 2, 39 | 37 |
| +N29I | S/B | 3, 4 | 1 |
| + R122H | S/B | 3, 3 | 0 |
| + Other | S/B | 24, 40 | 16 |
| + R122H | S/B | 3, 32 | 30 |
| + R122H | S/B | 7, 32 | 25 |
| + R122H | S/B | 5, 32 | 27 |
| + R122H | S/B | 1, 10 | 9 |
| + R122H | S/B | 9, 13 | 4 |
S, sisters; B, brothers; S/B, sister and brother.