Table 1

Polymorphisms in RET and EDNRB genes

	Alleles in controls			Alleles in patients
Gene	No	Frequency		No	Frequency	Position	Nucleotide	Amino acid
RET	29	0.141		94	0.770	Exon 2	390 A	45 A
RET	177	0.859		28	0.230		390 G	45 A
RET	—	—		121	0.992	Exon 3	570 C	125 V
RET	—	—		1	0.008		570 A	125 V
RET	—	—		77	0.631	Exon 7	1491 G	432 A
RET	—	—		45	0.369		1491 A	432 A
RET	—	—		75	0.615	Exon 13	2502 C	769 L
RET	—	—		47	0.385		2502 G	769 L
RET	—	—		92	0.754	Exon 15	2907 C	904 S
RET	—	—		30	0.246		2907 G	904 S
EDNRB	54	0.931		106	0.883	Exon 1	ATG-148A	5' UTR
EDNRB	4	0.069		14	0.117		ATG-148G	5' UTR
EDNRB	48	0.857		109	0.924	Exon 1	c169G	57G
EDNRB	8	0.143		9	0.076		c169A	57S
EDNRB	49	0.875		96	0.828	Exon 4	c818A+c875T	273K+292F
EDNRB	7	0.125		20	0.172		c818G+c875G	273R+292C

Allele frequencies, nucleotides affected, and amino acid exchange are given for the observed polymorphisms of the respective genes.
— , not examined.