Interleukin 1 receptor antagonist gene (IL-1RN) genotypes in controls, patients with ulcerative colitis, and in subgroups of patients with ulcerative colitis according to disease phenotype
| IL-1RN genotype | ||||||
|---|---|---|---|---|---|---|
| n | 1,1 | 1,2 | 2,2 | IL-1RN*2 carriage (%) | IL-1RN*2 frequency (%) | |
| Controls | 827 | 456 | 317 | 54 | 44.9 | 25.7 |
| Ulcerative colitis | 320 | 155 | 139 | 26 | 51.6 | 29.8 |
| Extensive colitis | 124 | 55 | 58 | 11 | 55.6 | 32.2 |
| Non-extensive colitis | 196 | 100 | 81 | 15 | 49.0 | 28.3 |
| Colitis requiring colectomy | 80 | 36 | 37 | 7 | 55.0 | 31.9 |
Extensive ulcerative colitis is defined as disease where inflammation extends beyond the splenic flexure while non-extensive disease refers to disease where the inflammation is limited to the left colon and includes left sided colitis, proctosigmoiditis, and proctitis.