Total 5-aminosalicylic acid (5-ASA +N-acetyl-5-ASA) faecal and urinary recovery (as percentage of ingested dose) of Asacol, Pentasa, and olsalazine in volunteers with normal or rapid transit time (TT) and in patients with inactive or active ulcerative colitis
| Healthy volunteers | Ulcerative colitis patients | ||||
|---|---|---|---|---|---|
| Drug | Normal TT | Rapid TT | Inactive | Active | |
| Total faecal 5-ASA | |||||
| Asacol | 23–40 | 48 | 44–53 | 60–90 | |
| Pentasa | 16–47 | 29–52 | 38–40 | 57 | |
| Olsalazine | 47 | 79 (53% unsplit) | 39–53 | 65 (47% unsplit) | |
| Total urinary 5-ASA | |||||
| Asacol | 13–36 | 10–31 | 17–35 | 16 | |
| Pentasa | 26–56 | 14–28 | 25–36 | 23 | |
| Olsalazine | 19–25 | 5 | 9–22 | 5 | |
Data taken from references48–54