Effect of a single application of a gel containing different phenylephrine concentrations on maximum anal resting pressure (MRP)
| Phenylephrine concn | Baseline MRP | MRP at 1 h | p1-150 | MRP at 2 h | p1-150 |
| Placebo | 35.5 (29–68) | 42.5 (31–64) | N/A | 48.0 (30–58) | N/A |
| 10% | 35.5 (19–77) | 48.0 (28–82) | 0.122 | 63.5 (32–76) | 0.068 |
| 20% | 38.0 (29–60) | 54.0 (33–81) | 0.170 | 56.0 (30–80) | 0.224 |
| 30% | 37.0 (28–68) | 65.0 (32–77) | 0.002 | 67.5 (29–80) | 0.002 |
| 40% | 43.0 (29–60) | 69.5 (28–89) | 0.004 | 63.5 (31–82) | 0.006 |
Values are median (range).
Results from 10 patients with passive faecal incontinence. Values at one and two hours were compared with values pretreatment (baseline). Subjects were studied on five separate days.
↵1-150 Comparison with placebo using Friedman multiple comparisons (Boneferroni corrected value).