Table 1

Mean villus surface area, length, diameter and crypt depth

Villus surface area (μm2) Villus length (μm) Villus diameter (μm) Crypt depth (μm) Villi/mm bowel
AR control, n=5516 120 (585)312 (8)51 (1)56.9 (1.3)13.4
AR low dose rEpo (n=55)17 950 (725)354 (8)1-170 50 (2)61.8 (2.5)17.41-151
AR high dose rEpo (n=39)21 250 (722)1-170 401 (9)1-170 53 (1)54.9 (1.6)15.41-164
NP control (n=38)14 800 (1028)298 (14)52 (2)52.2 (1.3)15.4
NP rEpo treated dam (n=39)17 400 (716)1-150 361 (13)1-165 48 (2)49.8 (1.6)17.3
  • AR control, artificially raised pups; AR low dose rEpo, artificially raised pups, 200 U/kg/day enteral human recombinant erythropoietin (rEpo); AR high dose rEpo, artificially raised pups, 1000 U/kg/day enteral rEpo; NP control, nursing pups control; NP rEpo treated dam, nursing pups, dam treated with 200 U rEpo/day intraperitoneally.

  • 1-150 p<0.05,

  • 1-165 p<0.001 compared with pups nursing from rEpo treated dam;

  • 1-151 p<0.05,

  • 1-164 p<0.01,

  • 1-170 p<0.0001 compared with artificially raised control pups.

  • Values are mean (SEM) or number.