Author/year
|
No patients
|
Drug dose (mg/day)
|
Duration (day)
|
Urinary Na output (mmol/day)
|
Creatinine clearance or
GFR
(ml/min)
|
Urine volume (ml/day)
|
MAP
(mm Hg)
|
Saruta, 198327
| 6 | SQ14225 75 mg | 7 | 100 (5) to 165 (16) in 5 of 62-150
| Unchanged | 1400 (210) to 1800 (180)2-150
| 92.6 (7) to 87 (7) |
| | | | | | | |
Brunkorst, 198928
| 14 | Captopril 12.5 mg for 5 days then 25 mg for 5 days | 10 | 70 to 1252-150
| 53.7 (7.8) to 66.9 (15.1) | Fluid balance: +200 to –6002-150
| 84 (2.9) to 78.4 (2.9) |
| | | | | | | |
Ibarra, 199229
| 9 | Captopril 75 mg | 21 | 36.7 (9.5) to 103 (13.8) 7 of 9 patients2-150
| NA | NA | 86.9 (2.6) to 80.2 (3.7) |
| | | | | | | |
Van Vliet, 199230
| 8 | Captopril from 9 to 37.5 mg | 20 | 72.8 (35.2) to 1128.5 (63.5) in 4 responders2-150
| NA | 1207 (456) to 1646 (395) in 4 responders2-150
| 79.8 (7.3) to 72.6 (9) in 4 responders |
| | | | 40.9 (35) to 42.4 (32) in 4 non-responders | | 1107 (334) to 1375 (424) in 4 non-responders | 86.3 (5.9) to 84.2 (9.4) in 4 non-responders |
| | | | | | | |
Wood, 198531
| 4 | Captopril from 18.75 to 37.5 mg | 3 | 14.25 to 6.52-152
| 70 to 462-152
| NA | 87 to 782-152
|
| | | | | | | |
Tsai, 199632
| 25 | Captopril 6.25 tds | 14 | 20 (5) to 26 (6) | 45 (11) to 40 (10) | 790 (111) to 725 (85) | 88 (3) to 86 (4) |
| 25 | Placebo | 14 | 21 (6) to 18 (4) | 41 (10) to 38 (11) | 653 (78) to 750 (97) | 86 (2) to 85 (3) |
| | | | | | | |
Ohnishi, 199433
| 10 | Enalapril 10 mg | 8 | 73 to 1102-152
2-150
| 47 to 602-152
2-150
| 1800 to 23002-152
2-150
| NA |
| | | | | | | |
Amarapurkar, 199434
| 8 | Enalapril 10 mg | 7 | NA | 46.5 (15.4) to 73.2 (19.7)2-150
| NA | NA |