Table 3

Characteristics of individuals and tumours with MSI-H tumours but with no mismatch repair defect, as determined by immunostaining (false negative IHC)

ID Age Sex AC Stage Site IEL Mucin Grade p53 K-ras
FN162FNoIAsC+NoModWildMut
FN262MNo2-150 IIAsC+YesPoorWildWild
FN367FNoIITCNoModMutWild
FN477FNoIITCNoModMutWild
FN583FNoIVCaecum+YesPoorWildWild
FN684FNoIVSCNoPoorWildWild
  • AC, Amsterdam criteria, IEL, intraepithelial lymphocytes, Mut, mutant, TC, transverse colon, AsC, ascending colon, SC, sigmoid colon; MSI-H, high level of microsatellite instability.

  • 2-150 This patient had three first degree relatives with either breast or gastric carcinoma.