Table 3

Clinical and biological data on 12 H63D homozygotes with a phenotype of hereditary haemochromatosis (HH)

							Liver biopsy			Body iron removed
Patient No	Sex	Age^3-150 (y)	Family history	Transferrin saturation (%)	Serum ferritin (μg/l)	HII	Fibrosis	Cirrhosis	HCC	Amount (g)	Duration (months)
1	F	35	HH, HCC	93	991	11.03	Yes	No	—	6.9	33
2	F	48	No	75	4816	6.4	Yes	Yes	—	11.4	63
3	M	39	No	68	1000	nd	nd	nd	—	10	66
4	M	40	No	72	1498	2.4	No	No	—	1.8	16
5	M	43	HH	47	987	1.47	No	No	—	27	198
6	M	47	No	50	886	nd	No	No	—	12.6	102
7	M	54	HH	51	1270	2.69	Yes	No	—	3	24
8	M	55	HH	47	645	2.24	No	No	—	2.7	16
9	M	63	No	63	1320	nd	Yes	No	—	9	49
10	M	65	HC	61.5	1410	4.06	Yes	Yes	Yes	0	0
11	M	75	No	95	2220	2.57	No	No	—	2.4	10
12	M	77	No	49	1220	2.12	Yes	Yes	Yes	0.2	0.5
Mean		53.4		64.2	1522					7.3
(SD)		(14)		(17)	(1100)					(7.6)

HH, hereditary haemochromatosis; HCC, hepatocarcinoma; HII, hepatic iron index; nd, not determined.
Normal range: transferrin saturation 23–43%; serum ferritin: men 40–300 μg/l, women 30–185 μg/l.
↵3-150 Age at diagnosis.