Table 3

Assessment of post-immunisation gastritis and Helicobacter felis colonisation. Long term assessment of post-immunisation gastritis and H felis colonisation. Bacterial colonisation and gastric pathology were assessed in control, infected, or immunised/challenged mice, 3, 6, 12, and 18 months post-challenge with H felis

Group		Time point (months)		Antrum				Body		Lymphoid aggregates / follicles		GAIS	Atrophy	Submucosal inflammation	Colonisation grade
Group		Time point (months)		Neutrophils	CI			Neutrophils	CI	Lymphoid aggregates / follicles		GAIS	Atrophy	Submucosal inflammation	Colonisation grade
Non-infected	3	1 (0–1)	1 (1)		0 (0–1)	1 (0–1)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)
	6	0 (0–1)	0 (0–1)		0 (0)	0 (0–1)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)
	12	0 (0–1)	0 (0–1)		0 (0–1)	0 (0–1)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)
	18	0 (0)	0 (0–1)		0 (0)	0 (0–1)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)
Infected	3	1 (1–3)	2 (1–2)		1.5 (0–3)	2 (1–4)	3.5 (0–8)	2 (0–10)	0 (0–2)	1 (0–3)	2.75 (1.5–4)
	6	2 (1–2)	2 (1–3)		3 (1–4)	3 (2–5)	5 (2–11)	7 (0–11)	1 (0–3)	2.5 (0–4)	3 (1.5–3.5)
	12	2 (1–3)	2.5 (1–3)		3 (1–4)	3 (2–5)	2.5 (0–10)	5 (0–25)	1 (0–2)	3 (0–5)	3.5 (1.5–4)
	18	1 (0–4)	2 (1–3)		2 (0–6)	4 (1–5)	2 (1–10)	8 (0–24)	2 (0–3)	4 (1–5)	2.75 (0.5–4)
Immunised/ challenged	3	2 (1–3)	2 (1–3)		5 (2–5)^3-150	3 (2–4)	0 (0–2)^3-151	12 (0–21)^3-150	2.5 (1–3)^3-150	3 (1–4)	1 (0–2)^3-151
	6	2 (1–3)	2 (1–2)		3 (1–4)	3.5 (1–5)	1 (0–5)^3-151	8 (0–12)	2.5 (0–3)	3 (0–4)	0.75 (0–3)^3-151
	12	2 (0–3)	2 (0–3)		1.5 (0–5)	3.5 (0–6)	0 (0–2)^3-151	1 (0–3)	2 (0–3)	3 (0–4)	0 (0–1)^3-151
	18	1 (0–3)	2 (1–3)		2 (1–3)	4 (1–5)	0 (0–5)^3-151	2 (0–16)	2 (0–3)	3 (0–5)	1.5 (0–4)

CI, chronic inflammation; GAIS, gland active inflammatory score.
All scores are median (range).
↵3-150 Significantly greater than the corresponding value in the infected control group (p<0.0125; Mann-Whitney);
↵3-151 significantly lower than the corresponding value in the infected control group (p<0.0125; Mann-Whitney).