Table 1

Stereoselective effects of cannabinoids on electrically evoked contractions of guinea pig isolated ileum or of the myenteric plexus-longitudinal muscle preparation (MPLM) of guinea pig ileum

  • 1-150 Concentration producing 50% inhibition of the twitch response. Cannabinoid vehicle used is shown in paraentheses.

  • 1-151 CP55940 has also been found to be more potent than CP56667 as a twitch inhibitor of mouse MPLM.15

  • CP56667 is the (+)-enantiomer of CP55940 and HU-211 is the (+)-enantiomer of HU-210 (dimethylheptyl-11-hydroxy-Δ8-tetrahydrocannabinol).

  • The samples of (+)-Δ8-THC and (+)-Δ9-THC used probably contained 5–10% of the corresponding (−)-enantiomer.16