Marker | Cannabinoid | Route and time of administration | Dose or potency | Effect on transit2-150 | Ref |
Charcoal (30 min) | Δ9-THC | sc immediately after marker | 10 or 30 mg/kg | −34% | 42 43 |
Δ8-THC | 30 mg/kg | −18% | |||
Charcoal (15 min) | Δ9-THC | po at 45 min before marker | LED=5 mg/kg | −31.5% | 44 |
CBN | LED=10 mg/kg | −15.8% | |||
Charcoal (15 min) | Δ9-THC | po at 45 min before marker | ED50=20 mg/kg | Inhibition | 45 |
Δ8-THC | ED50=13.5 mg/kg | Inhibition | |||
Charcoal (15 min) | Δ9-THC | po at 45 min before marker | 10 mg/kg | −58% | 46 |
Charcoal (15 min) | Δ9-THC | po at 45 min before marker | LED=5 mg/kg | −26% | 47 |
Radioactive marker | Δ9-THC | iv, po or icv | ED50=1.3 mg/kg (iv) | Inhibition | 39 |
(35 min) | CBN | immediately before marker | ED50=12 mg/kg (iv) | Inhibition | |
Nabilone | ED50=1.6 mg/kg (po) | Inhibition | |||
Δ9-THC | ED50=31.6 μg/mouse (iv) | Inhibition | |||
Δ9-THC | ED50=26.3 μg/mouse (icv) | Inhibition | |||
Charcoal (20 min) | AEA2-151 | sc at 60 min before marker | ED50=0.25 mg/kg | Inhibition | 48 |
PEA | 10 mg/kg | No effect | |||
Carmine (20 min) | (+)-WIN2-151 | ip at 20 min before marker | LED=0.25 mg/kg | ca. −30% | 49 |
Charcoal (20 min) | (+)-WIN2-151 | ip at 20 min before marker | LED=0.3 mg/kg | −34% | 50 |
Charcoal (20 min) | (+)-WIN2-151 | ip at 20 min before marker | ED50=169 nmol/mouse | Inhibition | 51 |
CBN2-151 | ED50=2760 nmol/mouse | Inhibition | |||
(+)-WIN2-151 | icv at 20 min before marker | ED50=104 nmol/mouse | Inhibition | ||
CBN2-151 | ED50=1829 nmol/mouse | Inhibition | |||
Charcoal (20 min)2-152 | (+)-WIN2-151 | ip at 20 min before marker | ED50=68 nmol/mouse | Inhibition | 51 |
CBN2-151 | ED50=1681 nmol/mouse | Inhibition | |||
(+)-WIN | icv at 20 min before marker | ED50=74 nmol/mouse | Inhibition |
Time after administration of the non-absorbable marker at which the mice were killed is shown in paraentheses.
sc, subcutaneously; iv, intravenously; po, orally; icv, intracerebroventricularly.
LED, lowest effective dose investigated; AEA, anandamide; CBD, cannabidiol; CBN, cannabinol; PEA, palmitylethanolamide; WIN, WIN55212.
↵2-150 Compared with vehicle control.
↵2-151 Antagonised by SR141716A at 1 mg/kg sc,48 0.62 mg/kg ip,49 0.3 mg/kg ip,50 or 16 nmol/mouse ip.51
↵2-152 Experiments performed with mice exhibiting croton oil induced diarrhoea.