Effect of SR141716A on transit of an orally administered non-absorbable marker through the small intestine of fasted mice
| Marker | Route and time of administration | Dose or potency | Effect on transit3-150 | Ref |
| Charcoal (20 min) | sc before marker | 1 mg/kg | +17.5% | 48 |
| Carmine (20 min) | ip at 20 min before marker | LED=1.25 mg/kg | ca. +33% | 49 |
| Charcoal (20 min) | ip at 20 min before marker | LED=1 mg/kg | +48% | 50 |
| Charcoal (20 min) | ip at 20 min before marker | ED50=375 nmol/mouse | Increase | 51 |
| icv at 20 min before marker | ED50=117 nmol/mouse | Increase | ||
| Charcoal (20 min) (croton oil treated mice) | ip at 20 min before marker | ED50=418 nmol/mouse | Increase | 51 |
Time after administration of the non-absorbable marker at which the mice were killed is shown in parentheses.
↵3-150 Compared with vehicle control.
LED, lowest effective dose investigated.