Release of myeloperoxidase activity (MPO, U/mg/h) into the intestinal lumen and tissue content of Evans blue (pmol/mg) in control segments and intestinal segments exposed to toxin A for three hours in the different series of experiments. Hexamethonium and nifedipine exeperiments were performed on acutely denervated intestinal segments
| MPO release | Evans blue concn | ||||
|---|---|---|---|---|---|
| Series | Control | Toxin A | Control | Toxin A | |
| Toxin A, 1 μg/ml | |||||
| Acutely denervated (6) | 0.26 (0.06) | 2.63 (0.52)3-a | 32 (2) | 52 (10)3-a | |
| Chronically denervated (5) | 1.02 (0.21)3-b | 2.79 (0.70)3-a | 30 (2) | 48 (4)3-a | |
| Hexamethonium (5) | 0.29 (0.05) | 0.80 (0.20)a b c | 30 (12) | 36 (13)3-a | |
| Nifedipine (6) | 0.51 (0.13) | 1.06 (0.26)b c | 20 (2)b c | 34 (10) | |
| Toxin A, 15 μg/ml | |||||
| Acutely denervated (6) | 0.33 (0.06) | 8.83 (1.48)a d | 29 (3) | 68 (10)3-a | |
| Chronically denervated (5) | 0.55 (0.19) | 5.02 (2.1)3-a | 33 (4) | 76 (5)a d | |
Numbers in parentheses indicate number of observations.
↵3-a Statistically significant compared with control;
↵3-b statistically significant compared with acutely denervated;
3-c statistically significant compared with chronically denervated;
3-d statistically significant compared with corresponding group of toxin A, 1 μg/ml.