Serum biochemistry at 48 hours after injection of galactosamine (GalN)
| Treatment | Bilirubin (μmol/l) | ALT (IU/l) | Albumin (g/l) |
|---|---|---|---|
| Rats injected with GalN (n=12) developed severe liver injury with significantly elevated levels of bilirubin, alanine transaminase (ALT), and albumin compared with controls (n=12). Rats treated with Bosentan either 24 hours prior to or 24 hours post GalN injection had a similar degree of liver injury. | |||
| Groups: control (n=12), GalN (GalN) (n=12), Bosentan+saline (Bos control) (n=4), Bosentan given 24 hours prior to GalN injection (Bos pre-GalN) (n=8), and Bosentan given 24 hours after GalN injection (Bos post-GalN) (n=12). | |||
| Values are mean (SEM). | |||
| *p<0.05, ***p<0.001, compared with control animals. | |||
| Control | 0.8 (0.1) | 63 (4) | 31 (1.0) |
| GalN | 148 (6)*** | 8857 (1057)*** | 28 (0.7)* |
| Bos control | 0.5 (0) | 77 (11) | 32 (0.5) |
| Bos pre-GalN | 118 (20)*** | 8556 (1754)*** | 27 (0.5)* |
| Bos post-GalN | 108 (5)*** | 9191 (933)*** | 27 (0.6)* |