Table 3

Interferon responsiveness (represented by the case number of complete responders/non-responders) in three different viral types (W, J, and genotype 2a) by univariate analysis according to clinical, histological, and virological variants

Sex Male (n=80) Female (n=41) Odds ratio 95% CI p Value
 W type4/236/80.230.055–0.9830.047
 J type6/194/90.710.160–3.1520.468
 2a17/117/71.550.425–5.6140.508
Age (y) <50 (n=56) ⩾50 (n=65) Odds ratio 95% CI p Value
 W type6/174/141.240.290–5.2570.775
 J type6/114/172.320.540–9.9540.258
 2a10/614/121.430.401–5.0880.582
Transfusion history Yes (n=43) No (n=78) Odds ratio 95% CI p Value
 W type5/155/161.070.256–4.4380.929
 J type8/102/187.201.443–35.9140.016
 2a3/221/161.140.170–7.6620.891
Grading score3-150 1–8 (n=65) 9–18 (n=56) Odds ratio 95% CI p Value
 W type4/96/221.630.372–7.1370.517
 J type4/196/90.320.073–1.3600.122
 2a17/127/61.210.326–4.5300.773
Staging score3-160 0–1 (n=70) 2–4 (n=51) Odds ratio 95% CI p Value
 W type5/155/161.070.256–4.4380.929
 J type5/175/110.650.152–2.7540.556
 2a16/128/61.001.000
HCV RNA (×106eq/ml) <1.0 (n=56) ⩾1.0 (n=65) Odds ratio 95% CI p Value
 W type9/31/2884.0014.039–502.613<0.0001
 J type9/21/26117.0017.817–768.332<0.0001
 2a23/101/818.403.002–112.7890.0016
ISDR Wild-type (n=40) Mutant-type (n=39) Odds ratio 95% CI p Value
 W type4/196/120.420.100–1.7720.238
 J type1/169/120.080.013–0.5530.010
  • 3-150 Grading score is a total of components 1, 2, and 3 of the histological activity index (HAI) score according to Knodel and colleagues.15

  • 3-160 Staging score is according to Desmet and colleagues.14

  • HCV, hepatitis C virus; ISDR, interferon sensitivity determining region.