Patient demographics, biochemical, and liver biopsy data for patients homozygous for Cys282Tyr and His63Asp HFE mutations. Two patients homozygous for the His63Asp mutation did not have liver iron concentration assessed
| Homozygous | Age (y)/sex | Serum ferritin (ng/ml) | Transferrin saturation (%) | Grade of inflammation (0–18) | Stage of fibrosis (0–6) | Stainable iron hepatocyte (0–4) | Stainable iron macrophage (0–4) | Liver iron concentration (μg/g) | Hepatic iron index |
|---|---|---|---|---|---|---|---|---|---|
| Cys282Tyr | 22/female | 177 | 108.8 | 4 | 1 | 2.5 | 0.5 | 3240 | 2.52 |
| Cys282Tyr | 30/female | 130 | 24.3 | 4 | 1 | 0.5 | 0 | 1250 | 0.75 |
| Cys282Tyr | 32/male | 492 | 108.6 | 2 | 1 | 2 | 1 | 1780 | 1 |
| His63Asp | 35/female | 6 | 12.5 | 3 | 0 | 0 | 0 | 70 | 0.04 |
| His63Asp | 29/male | 323 | 19.7 | 6 | 2 | 0 | 0 | 840 | 0.52 |
| His63Asp | 45/male | 93 | 56.1 | 4 | 1 | 0 | 0 | — | — |
| His63Asp | 46/male | 213 | 45.6 | 6 | 6 | 0 | 0 | — | — |