Relationship between HFE genotype, serum iron indices, liver biopsy findings, stainable iron, and hepatic iron indices
| His63Asp/Cys282Tyr (n=8) | Cys282Tyr/WT (n=26) | His63Asp/WT (n=33) | WT/WT (n=90) | p Value | |
|---|---|---|---|---|---|
| Serum ferritin (ng/ml) (mean (SD)) | 138 (145) | 106 (115) | 171 (270) | 162 (369) | 0.94 |
| Serum iron (μmol/l) (mean (SD)) | 25.1 (10.1) | 17.8 (7.1) | 26.1 (12.4) | 22.7 (11.7) | 0.06 |
| Serum transferrin (g/l) (mean (SD)) | 2.4 (0.3) | 2.8 (0.6) | 2.8 (0.3) | 3.1 (1.6) | 0.01 |
| Transferrin saturation (%) (mean (SD)) | 45.9 (18.1) | 32.2 (15.4) | 41.0 (17.6) | 34.8 (20.9) | 0.21 |
| Grade of inflammation (0–18) | 5 (1–6) | 4 (1–9) | 4 (1–9) | 5 (0–13) | 0.22 |
| Interface hepatitis (0–4) | 1 (0–2) | 1 (0–3) | 1 (0–2) | 1 (0–4) | 0.05 |
| Confluent necrosis (0–6) | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–6) | 0.20 |
| Parenchymal inflammation (0–4) | 2 (1–3) | 2 (0–3) | 2 (0–4) | 2 (0–4) | 0.14 |
| Portal inflammation (0–4) | 1 (0–2) | 1 (1–4) | 1 (0–3) | 1 (0–3) | 0.59 |
| Stage of fibrosis | |||||
| 0 | 3 | 5 | 8 | 10 | 0.09 |
| 1 | 3 | 11 | 14 | 38 | |
| 2 | 2 | 6 | 7 | 23 | |
| 3 | 0 | 2 | 4 | 10 | |
| 4 | 0 | 1 | 0 | 3 | |
| 5 | 0 | 0 | 0 | 1 | |
| 6 | 0 | 1 | 0 | 5 | |
| Stainable iron—hepatocyte | |||||
| 0 | 5 | 22 | 29 | 82 | 0.06 |
| 1 | 2 | 4 | 3 | 5 | |
| 2 | 1 | 0 | 1 | 3 | |
| Stainable iron—macrophage | |||||
| 0 | 6 | 24 | 31 | 83 | 0.28 |
| 1 | 1 | 2 | 1 | 5 | |
| 2 | 1 | 0 | 1 | 1 | |
| 3 | 0 | 0 | 0 | 1 | |
| No with hepatic iron estimation | 5 | 22 | 24 | 64 | |
| Liver iron concentration (μg/g) (mean (SD)) | 462 (286) | 535 (321) | 508 (320) | 544 (568) | 0.82 |
| Hepatic iron index (mean (SD)) | 0.23 (0.10) | 0.26 (0.15) | 0.24 (0.14) | 0.25 (0.22) | 0.66 |