Liver function in workers according to the number of exposures to 5-nitro-o-toluidine
| Case No | Age (y) | No of exposures | AST (IU/l) | ALT (IU/l) | GGT (IU/l) | ALP (IU/l) | TBil (mg/dl) | ALB (g/dl) | TC (mg/dl) | PT (INR) |
|---|---|---|---|---|---|---|---|---|---|---|
| AST, aspartate aminotransferase; ALT, alanine aminotransferase; GGT, gamma glutamyl transpeptidase; ALP, alkaline phosphatase; TBil, total bilirubin; ALB, albumin; TC, total cholesterol; PT, prothrombin time. | ||||||||||
| **p<0.01 compared with backup workers (unpaired Student's t tests). | ||||||||||
| Principally exposed workers | ||||||||||
| 1 | 49 | 15 | 231 | 426 | 477 | 717 | 1.3 | 3.6 | 153 | 0.94 |
| 2 | 59 | 20 | 1224 | 2510 | 301 | 780 | 1.6 | 3.9 | 158 | 0.96 |
| 3 | 57 | 18 | 1107 | 1996 | 247 | 743 | 3.6 | 3.7 | 131 | 1.38 |
| 4 | 49 | 12 | 82 | 99 | 116 | 304 | 0.6 | 3.8 | 161 | — |
| 5 | 57 | 17 | 1344 | 1914 | 288 | 928 | 1.0 | 3.7 | 123 | 1.23 |
| 6 | 57 | 15 | 377 | 389 | 80 | 385 | 0.4 | 4.1 | 174 | 0.94 |
| Mean (SEM) | 54.3 (4.3) | 16.2 (1.1)** | 728 (228)** | 1222 (421)** | 252 (58)** | 643 (100)** | 1.4 (0.5) | 3.8 (0.1) | 153 (9) | 1.09 (0.09) |
| Backup workers | ||||||||||
| 7 | 52 | 3 | 93 | 190 | 129 | 256 | 1.0 | 3.6 | 246 | — |
| 8 | 48 | 2 | 20 | 19 | 24 | 256 | 0.4 | 4.1 | 196 | — |
| 9 | 55 | 2 | 21 | 37 | 54 | 209 | 0.8 | 4.2 | 151 | — |
| 10 | 57 | 2 | 23 | 23 | 40 | 184 | 0.9 | 4.2 | 162 | — |
| 11 | 45 | 2 | 21 | 11 | 52 | 276 | 0.9 | 3.5 | 205 | — |
| 12 | 47 | 2 | 15 | 17 | 20 | 208 | 0.8 | 4.2 | 152 | — |
| 13 | 53 | 1 | 20 | 23 | 26 | 209 | 0.4 | 3.8 | 174 | — |
| 14 | 58 | 1 | 24 | 24 | 22 | 236 | 1.0 | 3.6 | 157 | — |
| 15 | 47 | 1 | 15 | 33 | 22 | 236 | 0.4 | 3.9 | 173 | — |
| Mean (SEM) | 51.3 (4.8) | 1.8 (0.2) | 28 (8) | 42 (19) | 43 (12) | 227 (9) | 0.7 (0.1) | 3.9 (0.1) | 180 (10) | — |