Effect of bile salts on methionine adenosyltransferase (MAT) activity in vitro
| Bile salt tested | |||
|---|---|---|---|
| TC | UDC | DC | |
| MAT activity was measured in vitro in the presence of increasing concentrations of the three bile salts studied (taurocholate (TC), ursodeoxycholate (UDC), or deoxycholate (DC); n=4–6 measurements at every point). | |||
| Results are expressed as percentage with respect to those obtained in samples in which no bile salts were added. | |||
| *p<0.05 with respect to corresponding values in the TC group. | |||
| Bile salt concn | |||
| 30 μM | 119.8 (11.0) | 115.6 (7.9) | 101.6 (2.3) |
| 500 μM | 102.1 (6.7) | 94.5 (1.5) | 95.2 (2.7) |
| 2 mM | 95.2 (6.4) | 79.5 (5.5) | 60.9 (12.7) |
| 6.6 mM | 79.2 (7.6) | 61.7 (2.4) | 34.6 (8.1)* |
| 10 mM | 73.4 (5.9) | 50.5 (5.2) | 36.1 (7.9)* |