Table 1

Clinical criteria for suspected hereditary non-polyposis colorectal cancer (HNPCC) designed by study group

Familes from categories 1–3 meet the clinical criteria for HNPCC proposed by the International Collaborative Group for HNPCC. CRC, colorectal cancer.

  1. Amsterdam criteria I

  2. Amsterdam criteria II

  3. Amsterdam criteria I or II on extended pedigree

  4. Amsterdam criteria including other HNPCC related cancers (stomach, biliary tract, urinary tract, ovary, pancreas, abdominal cancer)

  5. Amsterdam criteria I except that the youngest case of CRC was 50–55 years at the time of diagnosis

  6. Patients aged 40 years or younger with at least one CRC among family members

  7. Both proband and one first degree relative had CRC before the age of 55 years