ATP and energy charge potential (ECP) levels in ileal epithelium in Ussing chambers
| Colon cancer (n=8) | CD non-inflamed (n=5) | CD inflamed (n=4) | ||||
|---|---|---|---|---|---|---|
| Time | ATP | ECP | ATP | ECP | ATP | ECP |
| Data are given as median (25–75th percentiles) at the start of the experiment—that is, after 40 minutes of equilibration in Ussing chambers (0 minutes), and after 15 minutes exposure to vehicle or sodium caprate (C10). | ||||||
| ATP concentrations are given as μg/mg dry weight. | ||||||
| *Decreased ATP concentrations compared with vehicle experiments (p<0.05); †decrease compared with baseline values in the same group and compared with vehicle experiments in the two non-inflamed groups (p<0.05). | ||||||
| 0 min | 6.3 (5.2–6.7) | 0.71 (0.68–0.76) | 6.0 (5.3–7.1) | 0.73 (0.71–0.76) | 6.1 (4.9–6.5) | 0.72 (0.69–0.74) |
| 15 min vehicle | 6.0 (4.6–6.3) | 0.70 (0.68–0.74) | 5.6 (5.1–6.1) | 0.74 (0.70–0.77) | 3.6† (3.0–4.3) | 0.64† (0.62–0.67) |
| 15 min C10 | 2.1* (1.7–2.6) | 0.53* (0.51–0.57) | 2.4* (2.2–2.7) | 0.56* (0.50–0.59) | 2.3* (1.8–2.4) | 0.54* (0.47–0.56) |