Association of methylenetetrahydrofolate reductase (MTHFR) genotypes with clinicopathological features in colorectal cancer (CRC)
| n | CC (%) | CT (%) | TT (%) | p Value | |
|---|---|---|---|---|---|
| Values are number (%). | |||||
| MSI, microsatellite instability. | |||||
| p values for χ2 test comparing proportions of CC and TT between groups. | |||||
| Sex | |||||
| Male | 231 | 115 (50) | 96 (41) | 20 (9) | |
| Female | 270 | 134 (50) | 101 (37) | 35 (13) | 0.19 |
| Site | |||||
| Distal | 223 | 120 (54) | 79 (35) | 24 (11) | |
| Proximal | 278 | 129 (46) | 118 (43) | 31 (11) | 0.54 |
| Stage | |||||
| Dukes' B | 186 | 94 (50) | 64 (35) | 28 (15) | |
| Dukes' C | 315 | 155 (49) | 133 (42) | 27 (9) | 0.07 |
| Grade | |||||
| Moderate/well | 431 | 210 (49) | 174 (40) | 47 (11) | |
| Poor | 48 | 29 (61) | 15 (31) | 4 (8) | 0.38 |
| MSI status | |||||
| − | 203 | 101 (50) | 83 (41) | 19 (9) | |
| + | 75 | 28 (37) | 35 (47) | 12 (16) | 0.05 |
| p53 mutation | |||||
| − | 303 | 148 (49) | 116 (38) | 39 (13) | |
| + | 153 | 73 (48) | 66 (43) | 14 (9) | 0.35 |
| K-ras mutation | |||||
| − | 180 | 86 (48) | 77 (43) | 17 (9) | |
| + | 81 | 51 (63) | 23 (28) | 7 (9) | 0.44 |