Effect of glucagon-like peptide-1(7–36)amide (GLP-1) on fundus motility and perception of isobaric distension
| Parameter | Saline | GLP-1 0.3 pmol/kg/min | GLP-1 0.9 pmol/kg/min |
|---|---|---|---|
| Mean (SEM) of absolute values (n=11); values for the basal period preceding intravenous infusion of saline or GLP-1 are shown in parentheses. | |||
| *p<0.05 versus saline; †p<0.05 versus GLP-1 0.3 pmol/kg/min. | |||
| P½, pressure above minimal distending pressure at half the maximum bag volume; σ, instantaneous slope of the compliance curve calculated as volume against 1/pressure; a reduction in P½12 and σ reflects an increase in compliance. | |||
| One way repeated measures ANOVA was used employing individual mean incremental values over basal values during the post-drug period for motility parameters recorded at operating pressure, or absolute values for parameters of compliance and perception, respectively. | |||
| Bag volume (ml) | (107.8 (5.3)) 121.1 (6.0) | (101.0 (6.8)) 162.9 (15.0)* | (99.7 (9.0)) 259.5 (17.2)*† |
| Volume waves (No/15 min) | (15.4 (1.0)) 15.8 (1.4) | (12.8 (1.0)) 8.5 (1.7)* | (13.2 (2.1)) 4.5 (1.2)*† |
| Volume wave index (l×s/15 min) | (21.0 (2.3)) 23.1 (2.3) | (17.3 (1.7)) 11.0 (2.9)* | (18.5 (3.3)) 5.2 (1.4)* † |
| Amplitude of volume waves (ml) | (74.5 (4.7)) 80.9 (4.4) | (67.9 (2.7)) 59.4 (4.2)* | (68.3 (5.6)) 55.5 (3.6)* |
| Duration of volume waves (s) | (33.4 (0.9)) 32.3 (1.1) | (34.4 (1.1)) 37.1 (1.9) | (36.4 (2.7)) 36.0 (2.8) |
| Linear compliance (ml/mm Hg) | −27.0 (3.5) | −42.6 (5.5)* | −63.6 (7.7)*† |
| Non-linear compliance σ | −6.1 (0.3) | −5.3 (0.4)* | −4.4 (0.3)*† |
| Non-linear compliance P½12 (mm Hg) | −7.2 (0.4) | −6.4 (0.4)* | −5.5 (0.4)*† |
| Cumulative perception score | −9.5 (1.0) | −11.4 (1.5) | −11.5 (0.9) |