TP53 mutations in colorectal carcinomas found at the same codons as in adenomas
| Adenomas* | Carcinomas† | |||||
|---|---|---|---|---|---|---|
| Normal | Codon | Mutant | No | % | No | % |
| *This study plus data from public databases.11,12 | ||||||
| †As in the public databases.11,12 | ||||||
| ‡Percentage of the 782 colorectal carcinomas described in the public databases.11,12 | ||||||
| §Gln144Stop mutation has been described in a herititary non-polyposis colorectal cancer.24 | ||||||
| Phe | 134 | Leu | 1 | 0.1‡ | ||
| Ser | 1 | 3.0 | 1 | 0.1 | ||
| Gln | 144 | His§ | 1 | 3.0 | ||
| Thr | 150 | Arg | 1 | 3.0 | ||
| Gly | 154 | Asp | 1 | 3.0 | 1 | 0.1 |
| Arg | 175 | Cys | 2 | 0.3 | ||
| Gly | 1 | 3.0 | 1 | 0.1 | ||
| His | 6 | 18.2 | 74 | 9.5 | ||
| Leu | 4 | 0.5 | ||||
| Pro | 1 | 0.1 | ||||
| Ser | 1 | 0.1 | ||||
| Arg | 213 | Gln | 1 | 0.1 | ||
| Leu | 1 | 0.1 | ||||
| Stop | 1 | 3.0 | 15 | 1.9 | ||
| Met | 237 | Frameshift | 1 | 0.1 | ||
| Ile | 6 | 0.8 | ||||
| Leu | 1 | 3.0 | 1 | 0.1 | ||
| Lys | 1 | 0.1 | ||||
| Ser | 241 | Cys | 1 | 3.0 | 2 | 0.3 |
| Frameshift | 2 | 0.3 | ||||
| Phe | 8 | 1.0 | ||||
| Gly | 244 | Asp | 2 | 0.3 | ||
| Cys | 3 | 0.4 | ||||
| Ser | 2 | 0.3 | ||||
| Val | 1 | 3.0 | 1 | 0.1 | ||
| Gly | 245 | Arg | 1 | 3.0 | ||
| Asp | 1 | 3.0 | 13 | 1.7 | ||
| Cys | 4 | 0.5 | ||||
| His | 1 | 0.1 | ||||
| Ser | 5 | 15.2 | 25 | 3.2 | ||
| Val | 4 | 0.5 | ||||
| Arg | 248 | Gln | 51 | 6.5 | ||
| Leu | 2 | 0.3 | ||||
| Trp | 1 | 3.0 | 54 | 6.9 | ||
| Phe | 270 | Cys | 1 | 0.1 | ||
| Ile | 1 | 3.0 | 3 | 0.4 | ||
| Arg | 273 | Cys | 1 | 3.0 | 32 | 4.1 |
| His | 3 | 9.1 | 27 | 3.5 | ||
| Arg | 282 | Gln | 3 | 0.4 | ||
| Leu | 1 | 0.1 | ||||
| Trp | 2 | 6.1 | 40 | 5.1 | ||
| Glu | 285 | Asp | 1 | 0.1 | ||
| Gln | 2 | 6.1 | ||||
| Lys | 2 | 0.3 | ||||
| Stop | 1 | 0.1 | ||||
| Arg | 290 | Frameshift | 1 | 3.0 | 1 | 0.1 |
| His | 1 | 0.1 | ||||