Comparison of symptomatology at diagnosis or screening and iron indices in male probands and in C282Y homozygotes identified through family screening with iron overload, as defined by transferrin saturation ≥52% and serum ferritin ≥300 μg/l
| Variable | Probands | Identified C282Y homozygotes with iron overload | p Value |
|---|---|---|---|
| Results are means (SD). | |||
| Age (y) | 48 (10) (n=21) | 42 (13) (n=31) | 0.082 |
| Transferrin saturation (%) | 81 (14) (n=21) | 80 (10) (n=31) | 0.620 |
| Serum ferritin (μg/l) | 1327 (846) (n=21) | 1049 (930) (n=31) | 0.059 |
| Fatigue | 14/19 (74%) | 17/31 (55%) | 0.183 |
| Arthropathy | 9/19 (47%) | 11/31 (35%) | 0.405 |
| Impotence | 2/15 (13%) | 5/26 (19%) | 1.00 |