Comparison of symptomatology at diagnosis or screening and iron indices in female probands and in female C282Y homozygotes identified through family screening with iron overload, as defined by transferrin saturation ≥52% and serum ferritin ≥200 μg/l
| Variable | Probands | Identified C282Y homozygotes with iron overload | p Value |
|---|---|---|---|
| Results are means (SD). | |||
| Age (y) | 36 (5) (n=7) | 39 (15) (n=14) | 0.600 |
| Transferrin saturation (%) | 82 (17) (n=7) | 72 (13) (n=14) | 0.173 |
| Serum ferritin (μg/l) | 811 (299) (n=7) | 419 (248) (n=14) | 0.003 |
| Fatigue | 6/6 (100%) | 6/14 (43%) | 0.041 |
| Arthropathy | 2/7 (29%) | 3/14 (21%) | 1.00 |