Scoring system for Crohn's disease68
| Histological variable | Grading |
|---|---|
| Each variable is scored independently. The total score is the sum of all individual scores (max = 16). | |
| 1: epithelial damage | 0 = normal; 1 = focal; 2 = extensive |
| 2: architectural changes | 0 = normal; 1 = moderate (>50%); 2 = severe (>50%) |
| 3: mononuclear cells in lamina propria | 0 = normal; 1 = moderate increase; 2 = severe increase |
| 4: polymorphonuclear cells in lamina propria | 0 = normal; 1 = moderate increase; 2 = severe increase |
| 5: neutrophils in epithelium | 1 = surface epithelium; 2 = cryptitis; 3 = crypt abscess |
| 6: erosion or ulceration | 0 = no; 1 = yes |
| 7: granuloma | 0 = no; 1 = yes |
| 8: number of biopsies affected (total: n=6 or more) | 0 = none; 1 = >33%; 2 = 33–66%; 3 = >66% |