IPMT: proportions of lesions exhibiting abnormalities in protein expression
| p53 accumulation | Cyclin D1 overexpression | p16INK4A loss** | p27KIP1 low expression | p21CIP1 low expression | pRb loss | Smad 4 loss* | |
|---|---|---|---|---|---|---|---|
| IPMT, intraductal papillary mucinous tumour; IPMC, intraductal papillary mucinous carcinoma. | |||||||
| Statistically significant difference between adenoma/borderline IPMT and IPMC: *p<0.03, **p<0.0001. | |||||||
| Adenoma/borderline IPMT | 3/10 (30%) | 4/10 (40%) | 1/10 (10%) | 3/10 (33%) | 2/10 (20%) | 0/6 (0%) | 0/10 (0%) |
| IPMC | 5/8 (63%) | 5/8 (63%) | 8/8 (100%) | 0/8 (0%) | 5/8 (63%) | 0/8 (0%) | 3/8 (38%) |
| Invasive carcinoma | 3/4 (75%) | 3/4 (75%) | 3/4 (75%) | 2/4 (50%) | 2/4 (50%) | 0/4 (0%) | 3/4 (75%) |