Risk of hepatitis C virus (HCV) in mother to child transmission in HCV-human immunodeficiency virus (HCV-HIV) coinfected patients
| Year, reference | No of coinfected mothers/HCV infected only | Location | No HCV infected children (%) in coinfected/HCV infected only (%) | Definition of HCV infection in the child | Factors associated with higher transmission |
|---|---|---|---|---|---|
| CS, caesarean section; VD, vaginal delivery; PCR, polymerase chain reaction. | |||||
| 199818 | 41/112 | USA | 7 (17.1%)/6 (5.4%) | PCR positive at 6 months | HIV (p=0.04), HCV viral load (p<0.001) |
| 199531 | 22/94 | Italy | 8 (36%)/0 (0%) | PCR positive at 12 months | HIV (p<0.001), HCV viral load (p=0.05) |
| 199732 | 165/80 | Italy | 25 (15.1%)/3 (3.7%) | PCR or HCV antibody positive at 18 months | HIV (p=<0.01), VD (p=0.06) |
| 199833 | 23/52 | Italy | 4 (17.4%)/2 (3.8%) | PCR positive at 6 months | HIV (p=0.06) |
| 200034 | 22/328 | UK, Ireland | 4 (18.6%)/21 (6.4%) | PCR positive at 1 month | HIV (p=0.06), VD with emergency CS v elective CS (p=0.04) |
| 200135 | 503/971 | EU | 70 (13.9%)/60 (6.6%) | PCR or HCV antibody positive at 18 months | OR (95% CI) for HCV transmission: HIV, OR 3.76 (CI 1.89–7.41) |
| 199336 | 51/15 | UK | 3 (5.8%)/1 (6.6%) | PCR positive at 12 months | HIV (NS) |
| 199537 | 53/17 | Italy | 12 (23%)/2 (12%) | PCR positive at any time | HIV (p=0.277) VD, p<0.05 |
| 199538 | 20/17 | Italy | 4 (20%)/2 (12%) | PCR positive at any time | HIV (NS) |
| 199839 | 73/49 | USA | 5 (7%)/2 (4%) | PCR positive at 18 months | HIV (NS) |