ISIS 2302 pharmacokinetics
| Pharmacokinetics | All ISIS 2302 2 mg/kg/2 h | ISIS 2302 subset: AUC >65 μg×h/ml |
|---|---|---|
| Cmax, maximum concentration; T1/2, half life; AUC, area under the curve; Cl, clearance;Vd, volume of distribution. | ||
| n | 181 | 9 |
| Cmax (μg/ml) | 14.83 (3.06) | 22.53 (2.48) |
| T1/2 (h) | 1.11 (0.19) | 1.55 (0.22) |
| AUC (μg×h/ml) | 42.46 (12.22) | 76.15 (10.0) |
| CL (ml/min/kg) | 0.85 (0.24) | 0.44 (0.055) |
| Vd (ml/kg) | 78.44 (10.89) | 58.97 (6.85) |