Laboratory values in group I (diseased control)
| Parameter | 0 h | 24 h | 48 h |
|---|---|---|---|
| Data are mean (SEM). | |||
| ICG, indocyanine green; TNF-α, tumour necrosis factor α. | |||
| *p<0.05, **p<0.01, ***p<0.001 versus 0 h (time of galactosamine injection). | |||
| Sodium (mmol/l) | 135 (2) | 141 (3) | 142 (2) |
| Potassium (mmol/l) | 3.5 (0.1) | 4.1 (0.1) | 3.7 (0.2) |
| Calcium (mmol/l) | 2.52 (0.08) | 2.66 (0.08) | 2.34 (0.13) |
| Protein (g/l) | 56 (2) | 64 (2) | 61 (2) |
| Total bilirubin (μmol/l) | 3 (1) | 37 (4)*** | 73 (4)*** |
| Alkaline phosphatase (U/l) | 143 (17) | 425 (64)** | 1048 (127)*** |
| Aspartate aminotransferase (U/l) | 42 (5) | 1568 (767) | 2753 (1070)* |
| Lactate dehydrogenase (U/l) | 1107 (117) | 3814 (1010)* | 7475 (1226)*** |
| Ammonia (μg/dl) | 92 (30) | 133 (55) | 565 (251)* |
| Bile acid (μmol/l) | 16 (7) | 479 (19)*** | 358 (23)*** |
| Lactate (mmol/l) | 14 (2) | 37 (10) | 52 (12)* |
| TNF-α (pg/ml) | 70 (2) | 76 (3) | 103 (13)** |
| Endotoxin (EU/ml) | 1.59 (0.30) | 3.98 (1.30) | 5.30 (1.69)* |
| Platelet (103/μl) | 289 (39) | — | 214 (90) |
| Activated clotting time (s) | 129 (8) | 163 (11) | 205 (5)** |
| ICG at 15 min (%) | 17 (3) | — | 57 (5)*** |