Comparative efficacy of JO 2871 on Escherichia coli heat stable toxin (E coli-sta) and Salmonella enteriditis lipopolysaccharide (LPS) induced diarrhoea according to the route of administration (oral (PO) v intravenous (IV) v intracerebroventricular (ICV))
| ED 50 (μg/kg) | |||
|---|---|---|---|
| IV | PO | ICV | |
| E coli-sta (70 μg/kg PO) | 0.1 | 20 | >10 |
| S enteriditis LPS (15 mg/kg IV) | 4×10−4 | 10 | >10 |