Patients with complete relief of symptoms | |||||||||
---|---|---|---|---|---|---|---|---|---|
BOND (n=642) | OPERA (n=606) | BOND+OPERA (n=1248) | |||||||
Treatment | All | PCP | SG | All | PCP | SG | All | PCP | SG |
PCP, primary care physician; SG, specialist gastroenterologist. | |||||||||
The split in patients between PCP and SG was 34% and 66% in the BOND study compared with 8% and 92% in the OPERA study. The difference in treatment response between the two studies was statistically significant when comparing active treatment (omeprazole 10 mg and 20 mg) with placebo (p=0.006) as well as when comparing each active drug with placebo (omeprazole 20 mg, p=0.04; omeprazole 10 mg, p=0.005). When adjusting for the type of investigator however, the difference in treatment response was not statistically significant. | |||||||||
Omeprazole 20 mg once daily | 42% | 34% | 47% | 34% | 56% | 32% | 38% | 38% | 38% |
Omeprazole 10 mg once daily | 43% | 49% | 40% | 29% | 15% | 30% | 36% | 44% | 34% |
Placebo | 26% | 14% | 32% | 31% | 11% | 32% | 28% | 13% | 32% |