Randomised, double blind, parallel group trials of H2 receptor antagonists versus placebo in dyspepsia
| Reference | No of patients | Trial period (weeks) | Treatment | Inclusion criteria: dyspepsia type | Placebo response rate (%) | Estimated therapeutic gain (95% CI) | Investigators' conclusion |
|---|---|---|---|---|---|---|---|
| CI, confidence interval. | |||||||
| La Brooy et al 197813 | 38 | 4 | Cimetidine | Ulcer-like | ? | ? | Not effective |
| Mackinnon et al 198214 | 21 | 6 | Cimetidine | Dyspepsia and duodenitis | 50 | 41 (35) | Effective |
| Bendtsen et al 198315 | 33 | 6 | Cimetidine | Ulcer-like | 58 | −15 (34) | Not effective |
| Kelbæk et al 198516 | 50 | 3 | Cimetidine | Epigastric pain | 62 | −8 (27) | Not effective |
| Nesland and Berstad 19859 | 90 | 4 | Cimetidine | Ulcer-like | 30 | 17 (20) | Effective |
| Delattre et al 198517 | 414 | 4 | Cimetidine | Epigastric pain | 57 | 20 (9) | Effective |
| Lance et al 198618 | 60 | 4 | Cimetidine | Epigastric pain/ ulcer-like | 54 | 8 (25) | Not effective |
| Nyrén et al 198619 | 105 | 3 | Cimetidine | Ulcer-like | 25 | 4 (17) | Not effective |
| Olubuyide et al 198620 | 45 | 4 | Ranitidine | ? | ? | ? | Not effective |
| Saunders et al 198621 | 221 | 6 | Ranitidine | Dyspepsia | 59 | 21 (12) | Effective |
| Gotthard et al 198822 | 118 | 6 | Cimetidine | Dyspepsia | 38 | 16 (18) | Effective |
| Hadi 198923 | 45 | 4 | Ranitidine | Dyspepsia | 45 | 55 (22) | Effective |
| Müller et al 199410 | 509 | 4 (2) | Ranitidine | Dyspepsia | 36 | 14 (9) | Effective |
| Singal et al 198924 | 56 | 4 | Cimetidine | Dyspepsia | 40 | 27 (25) | Effective |
| Hansen et al 199825 | 221 | 2 | Nizatidine | Dyspepsia | 62 | −8 (14) | Not effective |