Randomised, double blind, parallel group trials of cisapride versus placebo in dyspepsia
| Reference | No of patients | Trial period (weeks) | Inclusion criteria: dyspepsia type | Placebo response rate (%) | Estimated therapeutic gain (95% CI) | Investigators' conclusion |
|---|---|---|---|---|---|---|
| CI , confidence interval. | ||||||
| Coutant et al 19875 | 32 | 4 | Dysmotility-like | 36 | 44 (41) | Effective |
| Rösch 198726 | 118 | 4 | Dyspepsia | 31 | 50 (16) | Effective |
| De Nutte et al 198911 | 32 | 4 | Epigastric pain | 50 | 32 (21) | Effective |
| Jian et al 198927 | 28 | 6 | Dysmotility-like | ? | ? | Not effective |
| Agorastos et al 19916 | 36 | 4 | Dysmotility-like | ? | ? | Effective |
| Hausken and Berstad 199228 | 120 | 4 | Epigastric pain/discomfort | 40 | 10 (18) | Not effective |
| Van Outryve et al 19938 | 53 | 2 | Epigastric pain/burning | 22 | 43 (24) | Effective |
| Chung 199329 | 29 | 4 | Dysmotility-like | 20 | 51 (31) | Effective |
| Frazzoni et al 199330 | 28 | 4 | Dyspepsia | 69 | 21 (27) | Not effective |
| Wood et al 199331 | 11 | 4 | Epigastric pain/discomfort | ? | ? | Not effective |
| Kellow et al 199532 | 61 | 4 | Dyspepsia | 66 | −8 (23) | Not effective |
| Al-Quorain et al 199533 | 89 | 4 | Dyspepsia | 27 | 60 (16) | Effective |
| de Groot and de Both 199734 | 113 | 4 | Dyspepsia | 44 | 19 (19) | Not effective |
| Champion et al 199735 | 123 | 6 | Epigastric pain | 33 | 12 (20) | Not effective |
| Yeoh et al 199736 | 76 | 4 | Epigastric pain/discomfort | 50 | 5 (21) | Not effective |
| Hansen et al 199825 | 221 | 2 | Dyspepsia | 62 | 0 (14) | Not effective |