Influence of placebo, NG-monomethyl-l-arginine (l-NMMA) 4 mg/kg/h, and l-NMMA 8 mg/kg/h on gastric fundus tone and perception of gastric distension in seven healthy volunteers
| Treatment group | Parameter | Before drug | After drug |
|---|---|---|---|
| Administration of drug had no significant effect on any of the parameters studied. | |||
| MDP, minimum distending pressure. | |||
| Placebo | Slope (ml/mm Hg) | 76 (9) | 65 (10) |
| Intercept (ml) | 109 (45) | 137 (87) | |
| Perception pressure (mm Hg above MDP) | 2.0 (0.0) | 2.4 (0.4) | |
| Perception volume (ml) | 231 (57) | 306 (83) | |
| Discomfort pressure (mm Hg above MDP) | 8.0 (1.1) | 8.8 (0.8) | |
| Discomfort volume (ml) | 695 (110) | 710 (111) | |
| l-NMMA 4 mg/kg/h | Slope (ml/mm Hg) | 72 (13) | 53 (5) |
| Intercept (ml) | 58 (49) | 91 (31) | |
| Perception pressure (mm Hg above MDP) | 3.2 (0.5) | 3.2 (0.5) | |
| Perception volume (ml) | 301 (52) | 271 (54) | |
| Discomfort pressure (mm Hg above MDP) | 10.8 (1.3) | 10.4 (0.7) | |
| Discomfort volume (ml) | 756 (90) | 668 (66) | |
| l-NMMA 8 mg/kg/h | Slope (ml/mm Hg) | 70 (16) | 52 (7) |
| Intercept (ml) | 102 (87) | 167 (59) | |
| Perception pressure (mm Hg above MDP) | 2.4 (0.4) | 3.2 (1.2) | |
| Perception volume (ml) | 280 (78) | 357 (83) | |
| Discomfort pressure (mm Hg above MDP) | 8.8 (1.2) | 10.4 (0.4) | |
| Discomfort volume (ml) | 711 (141) | 711 (96) | |