Associations between methylation and clinicopathological features of colorectal cancer
| Methylation (%) | ||||||
|---|---|---|---|---|---|---|
| Feature (n) | p16 | MDR1 | MINT-2 | One | Two | Three |
| *p<0.2; †p<0.1; ‡p<0.05; §p<0.005. | ||||||
| Total (275) | 100 (36) | 67 (24) | 102 (37) | 141 (51) | 88 (32) | 40 (15) |
| Sex | ||||||
| Female (137) | 51 (37) | 35 (26) | 56 (41) | 70 (51) | 47 (34) | 25 (18) |
| Male (138) | 49 (36) | 32 (23) | 46 (33) | 71 (51) | 41 (30) | 15 (11)† |
| Age | ||||||
| <71 y (144) | 50 (35) | 35 (24) | 49 (34) | 69 (48) | 47 (33) | 18 (13) |
| ≥71 y (131) | 50 (38) | 32 (24) | 53 (40) | 72 (55) | 41 (31) | 22 (17) |
| Stage | ||||||
| II (72) | 21 (29) | 13 (18) | 20 (28) | 27 (38) | 16 (22) | 11 (15) |
| III (203) | 79 (39)* | 54 (27)* | 82 (40)† | 114 (56)‡ | 72 (36)‡ | 29 (14) |
| Site | ||||||
| Rectum (42) | 9 (21) | 2 (5) | 9 (21) | 15 (36) | 5 (12) | 0 (0) |
| Distal colon (77) | 20 (26) | 11 (14) | 18 (23) | 29 (38) | 16 (21) | 4 (5) |
| Proximal colon (152) | 71 (47)§ | 54 (36)§ | 75 (49)§ | 114 (64)§ | 67 (44)§ | 36 (24)§ |
| Grade | ||||||
| Well/moderate (211) | 62 (29) | 39 (19) | 65 (31) | 93 (44) | 55 (26) | 18 (9) |
| Poor (61) | 36 (59)§ | 27 (44)§ | 36 (59)§ | 46 (75)§ | 32 (53)§ | 21 (34)§ |