Systemic haemodynamics in patients with cirrhosis
| Cirrhosis (Child group) | ||||||
|---|---|---|---|---|---|---|
| A (n = 15) | B (n = 23) | C (n = 13) | Total cirrhosis (n = 51) | Controls (n = 13) | ANOVA | |
| Values are mean (SEM). | ||||||
| Significant difference (p<0.05) from: acontrols, bChild class A, and cChild class C; and (p<0.01) from dcontrols. | ||||||
| Arterial blood pressure (mm Hg) | ||||||
| Systolic | 143 (6) | 138 (4) | 126 (7) | 136 (3) | 143 (9) | |
| Diastolic | 69 (3) | 65 (2) | 60 (3) | 65 (2) | 67 (3) | |
| Mean | 94 (5) | 93 (3) | 84 (5) | 91 (2) | 98 (5) | |
| Right atrial pressure (mm Hg) | 3.1 (0.3) | 3.1 (0.5) | 3.4 (0.3) | 3.2 (0.2) | 3.2 (0.1) | |
| Cardiac output (l/min) | 6.21 (0.48) | 7.51 (0.37)a | 7.35 (0.52)a | 7.09 (0.26)d | 5.75 (0.29) | p = 0.02 |
| Heart rate (min−1) | 76 (4) | 72 (2) | 81 (4) | 75 (2) | 73 (2) | |
| Stroke volume (ml) | 82 (5) | 108 (6)a b | 93 (8) | 96 (4)a | 80 (5) | p<0.01 |
| Systemic vascular resistance (dyn s/cm5) | 1272 (83) | 1031 (72)a | 973 (84)a b | 1082 (48)d | 1398 (98) | p<0.005 |
| Plasma volume (ml/kg) | 51.9 (2.7) | 57.3 (2.7) | 55.2 (2.9) | 55.2 (1.6)a | 47.0 (3.3) | p<0.05 |
| Blood volume (ml/kg) | 82.4 (3.6) | 87.9 (3.9) | 82.5 (4.4) | 84.9 (2.3)a | 75.1 (5.4) | p<0.05 |
| Central blood volume (ml/kg) | 23.4 (1.7) | 22.9 (1.0) | 20.6 (1.4) | 22.5 (0.8) | 23.7 (2.6) | |
| Central circulation time (s) | 14.7 (0.6) | 13.5 (0.5)c | 11.3 (0.5)a b | 12.5 (0.4)a | 14.3 (1.1) | p<0.001 |
| Arterial O2 saturation (%) | 95 (0.6) | 95 (1.1) | 96 (0.7) | 95 (0.6) | 95 (1.1) | |
| Arterial pO2 (kPa) | 10.9 (0.4) | 11.1 (0.5) | 10.3 (0.7) | 11.2 (0.6) | ||
| Arterial pCO2 (kPa) | 4.9 (0.1) | 4.4 (0.1)a b | 4.1 (0.2)a b | 4.5 (0.1)d | 5.3 (0.1) | p<0.001 |
| Arterial pH | 7.41 (0.01) | 7.43 (0.01) | 7.45 (0.01)a b | 7.43 (0.005) | 7.41 (0.005) | p<0.01 |
| QT (s) | 0.381 (0.010) | 0.411 (0.011) | 0.389 (0.014) | 0.397 (0.007) | 0.397 (0.006) | |
| QTc (s½) | 0.428 (0.009) | 0.445 (0.010) | 0.447 (0.012)a | 0.440 (0.006) | 0.420 (0.006) | p<0.05 |
| QTc >0.440/QTc ⩽0.440 | 3/11 (n = 14) | 10/13 | 7/3 (n = 10) | 20/27 (n = 47) | 1/12 | |