Correlation of clinicopathological findings and clinical outcome parameters with cyclooxygenase 2 (COX-2) expression
| COX-2 expression | p Value | ||
|---|---|---|---|
| Low (n = 79) (n (%)) | High (n = 55) (n (%)) | ||
| *T1, tumour limited to the submucosa; T2, tumour infiltrates muscularis propria, but not adventitia; T3, tumour infiltrates adventitia; T4, tumour infiltrates adjacent structures. | |||
| †N0, no lymph node metastasis; N1, 1–6 lymph node metastases; N2, 7–15 lymph node metastases; N3, more than 15 lymph node metastases. | |||
| ‡Ia, T1N0M0; Ib, T1N1M0, T2N0M0; II, T1N2-3M0, T2N1M0, T3N0M0; IIIa, T2N2-3M0, T3N1M0; IIIb, T3N2-3M0, T4N1M0; IV, T4N2-3M0, anyTanyNM1. §THE, transhiatal resection; TTE, transthoracic resection. | |||
| ¶R0, microscopically radical; R1, microscopically non-radical; R2, macroscopically non-radical. | |||
| Patient characteristics | |||
| Age (mean (SD)) (y) | 64 (10) | 62 (9) | 0.3 |
| Sex | |||
| Male | 70 (88.6) | 43 (78.2) | 0.1 |
| Female | 9 (11.4) | 12 (21.8) | |
| Tumour characteristics | |||
| Depth of invasion* | |||
| T1 | 4 (5.1) | 1 (1.8) | 0.7 |
| T2 | 6 (7.6) | 3 (5.5) | |
| T3 | 64 (81.0) | 48 (87.3) | |
| T4 | 5 (6.3) | 3 (5.5) | |
| Lymph node involvement† | |||
| N0 | 17 (21.5) | 9 (16.4) | 0.08 |
| N1 | 37 (46.8) | 27 (49.1) | |
| N2 | 24 (30.4) | 13 (23.6) | |
| N3 | 1 (1.3) | 6 (10.9) | |
| Distant metastasis | |||
| M0 | 75 (94.9) | 53 (96.4) | 0.5 |
| M1 | 4 (5.1) | 2 (3.6) | |
| Differentiation grade | |||
| Well | 2 (2.5) | 1 (1.8) | 0.7 |
| Moderate | 29 (36.7) | 17 (30.9) | |
| Poor | 48 (56.4) | 37 (67.3) | |
| Tumour stage‡ | |||
| Ia | 3 (3.4) | 0 (0.0) | 0.7 |
| Ib | 1 (1.3) | 2 (3.6) | |
| II | 16 (20.3) | 10 (18.2) | |
| IIIa | 32 (40.5) | 25 (45.5) | |
| IIIb | 23 (29.1) | 16 (29.1) | |
| IV | 4 (5.1) | 2 (3.6) | |
| Operation type§ | |||
| THE | 58 (73.4) | 40 (72.7) | 0.5 |
| TTE | 21 (26.6) | 15 (27.3) | |
| Radicality of resection¶ | |||
| R0 | 58 (73.4) | 40 (72.7) | 0.5 |
| R1 | 21 (26.6) | 14 (25.5) | |
| R2 | 0 (0.0) | 1 (1.8) | |
| Clinical outcome | |||
| Locoregional recurrence | |||
| No | 41 (51.9) | 31 (56.4) | 0.6 |
| Yes | 38 (48.1) | 24 (43.6) | |
| Distant metastasis | |||
| No | 45 (57.0) | 31 (56.4) | 0.9 |
| Yes | 34 (43.0) | 24 (43.6) | |