Eleven year cumulated incidence of peptic ulcer disease (PUD) in 1994 by categories of baseline exposures: medication at study entry and five years preceding follow up. Unadjusted and sex and age adjusted odds ratios (OR, 95% confidence intervals (CI))
| Baseline exposure (reference category) | PUD incidence | Unadjusted | Sex and age adjusted | |||
|---|---|---|---|---|---|---|
| % | n | Odds ratio | 95% CI | Odds ratio | 95% CI | |
| Medication: previous or current daily, weekly, or monthly use. Blank cells indicate missing data or that numbers do not allow inferences. | ||||||
| Uspecified gastrointestinal drugs in 1982 | ||||||
| (Never-infrequent use) | 2.4 | 2071 | 1.0 | — | 1.0 | — |
| Previous use | 2.4 | 125 | 1.0 | 0.3;3.2 | 1.2 | 0.4;4.0 |
| Current use | 7.3 | 232 | 3.2 | 1.8;5.6 | 3.2 | 1.7;5.5 |
| Antirheumatic drug use at study entry in 1982 | ||||||
| (Never-infrequent use) | 2.9 | 2156 | 1.0 | — | 1.0 | — |
| Previous use | 2.6 | 190 | 0.9 | 0.4;2.3 | 0.9 | 0.3;2.2 |
| Current use | 2.4 | 82 | 0.8 | 0.2;3.5 | 0.7 | 0.2;3.0 |
| Antibiotic use at study entry in 1982 | ||||||
| (Never-infrequent use) | 2.8 | 2402 | 1.0 | — | 1.0 | |
| Previous use | 0.0 | 8 | — | |||
| Current use | 11.1 | 18 | 4.1 | 0.9;18.1 | 4.2 | 1.1;16.9 |
| Major tranquilliser use at study entry in 1982 | ||||||
| (Never-infrequent use) | 2.4 | 2381 | 1.0 | — | 1.0 | — |
| Previous use | 0.0 | 1 | ||||
| Current use | 2.0 | 37 | 2.3 | 0.5;9.9 | 2.2 | 0.5;9.6 |
| Minor tranquilliser use at study entry in 1982 | ||||||
| (Never-infrequent use) | 2.1 | 2373 | 1.0 | — | 1.0 | — |
| Previous use | 3.6 | 28 | 1.7 | 0.2;12.9 | 1.8 | 0.2;13.4 |
| Current use | 8.5 | 118 | 4.3 | 2.1;8.7 | 4.4 | 2.1;9.2 |
| Antacid use in the past 5 years | ||||||
| (Never-infrequent use) | 2.3 | 2367 | 1.0 | — | 1.0 | — |
| Previous use | 9.5 | 21 | 4.4 | 1.0;19.5 | 4.1 | 0.9;18.2 |
| Current use | 6.5 | 31 | 2.9 | 0.7;12.5 | 2.8 | 0.7;12.3 |
| H2 receptor antagonist use in the past 5 years | ||||||
| (Never-infrequent use) | 1.7 | 2371 | 1.0 | — | 1.0 | — |
| Previous use | 34.6 | 26 | 30.1 | 12.7;71.5 | 30.5 | 12.6;74.0 |
| Current use | 40.9 | 22 | 39.3 | 15.9;97.2 | 38.6 | 15.4;97.2 |
| Proton pump inhibitor use in the past 5 years | ||||||
| (Never-infrequent use) | 2.2 | 2397 | 1.0 | — | 1.0 | — |
| Previous use | 33.3 | 9 | 22.1 | 5.4;90.9 | 20.1 | 4.8;83.9 |
| Current use | 30.0 | 10 | 19.0 | 4.8;75.4 | 16.6 | 4.1;67.0 |
| NSAID use in the past 5 years | ||||||
| (Never-infrequent use) | 2.5 | 2256 | 1.0 | — | 1.0 | — |
| Previous use | 0.0 | 33 | ||||
| Current use | 2.3 | 130 | 0.9 | 0.3;3.0 | 0.9 | 0.3;3.0 |
| ASA use in the past 5 years | ||||||
| (Never-infrequent use) | 2.4 | 2305 | 1.0 | — | 1.0 | — |
| Previous use | 0.0 | 1 | ||||
| Current use | 2.7 | 113 | 1.1 | 0.3;3.6 | 0.9 | 0.3;3.1 |
| Paracetamol use in the past 5 years | ||||||
| (Never-infrequent use) | 2.3 | 2159 | 1.0 | — | 1.0 | — |
| Previous use | 0.0 | 9 | ||||
| Current use | 4.0 | 251 | 1.8 | 0.9;3.6 | 1.8 | 0.9;3.7 |
| Antibiotic use in the past 5 years | ||||||
| (Never-infrequent use) | 2.4 | 2390 | 1.0 | — | 1.0 | — |
| Previous use | 0.0 | 1 | ||||
| Current use | 7.4 | 27 | 3.3 | 0.8;14.2 | 3.2 | 0.7;13.7 |