Haplotype analysis of infection status and clinical manifestation of Helicobacter pylori infection
| Comparison groups | n (groups) | p Value |
|---|---|---|
| The table shows the comparative frequencies of the IFNGR1 haplotype described above. | ||
| Susceptibility to H pylori infection was tested by comparison of all H pylori positive patients (n: all subgroups: 66+112+166 = 344) against normal controls (top row). Genetic predisposition for complications of H pylori infection was tested by comparison of patients with moderate pathology (gastric or duodenal erosions, n = 66) and severe pathology (gastric or duodenal ulcers n = 112) against patients with mild or no pathology grouped together (no pathology, gastritis, or duodenitis, n = 166). Significance was assessed by a χ2 test of the global likelihood ratio of the case control haplotype estimations. | ||
| Infection status (normal controls versus all H pylori positive patients) | 311 v 344 | 0.39 |
| Moderate versus mild pathology in H pylori infected patients (gastric/duodenal erosions versus no pathology or gastritis/duodenitis) | 66 v 166 | 0.33 |
| Severe versus mild pathology in H pylori infected patients (gastric/duodenal ulcers versus no pathology or gastritis/duodenitis) | 112 v 166 | 0.61 |