Coeliac-type endomysial (EMA), reticulin (ARA), and jejunal antibody (JEA) binding of serum samples from gluten sensitive and control patients to transglutaminase 2 knockout (TG2−/−) and corresponding wild-type (TG2+/+) mouse tissues
| Coeliac disease (n=61) | Dermatitis herpetiformis (n=40) | Controls (n=34) | |
|---|---|---|---|
| Serum samples were tested at a dilution of 1:5 for immunofluorescence and at 1:200 for an enzyme linked immunosorbent assay (ELISA). | |||
| *Two additional patients showed EMA in the oesophagus, but not JEA or ARA in other tissues. | |||
| EMA/ARA/JEA+ on TG2+/+ mouse tissues | 57* | 39 | 0 |
| EMA/ARA/JEA+ on TG2−/− mouse tissues | 0 | 0 | 0 |
| EMA/ARA/JEA+ on TG2−/− mouse tissues coated with recombinant TG2 | 61 | 40 | 0 |
| Antihuman TG2 antibodies (ELISA) | 61 | 40 | 1 |