Percentage of children with hepatocellular carcinoma (HCC) and chronic hepatitis B virus (HBV)* who had HBV core gene mutations
| Codon | HCC (n=12) (% (n)) | Chronic HBV infection (n=23) (% (n)) | Mutation | p Value† |
|---|---|---|---|---|
| W, tryptophan; X, stop codon; S, serine; P, proline; L, leucine; V, valine; G, glycine; A, alanine; D, aspartic acid; T, threonine; C, cysteine; R, arginine; Q, glutamine. | ||||
| *From the 23 latest serum sample (after HBeAg seroconversion). | ||||
| Precore 28 | 58% (7) | 52.2% (12) | W→X | 0.73 |
| Core 21 | 8% (1) | 21.7% (5) | S→P or A | 0.32 |
| Core 65 | 33% (4) | 17.3% (4) | L→W or V | 0.29 |
| Core 74 | 33% (4) | 0 | S→G | 0.0032 |
| Core 87 | 33% (4) | 0 | S→G | 0.0032 |
| Core 131 | 8% (1) | 0 | A→D | 0.16 |
| Core 143 | 33% (4) | 4.3% (1) | L→P | 0.015 |
| Core 147 | 8% (1) | 21.6% (5) | T→C or S | 0.32 |
| Core 159 | 42% (5) | 0 | R→S | 0.0006 |
| Core 182 | 42% (5) | 4.3% (1) | Q→X | 0.0035 |