Table 1

Genetic changes detected in concurrent multiple colon tumours from patient COK169

			Germline p53 mutation		Somatic p53 mutation		Somatic APC mutation		Somatic K-ras mutation
Tumour	Size (mm)	Pathological diagnosis	Codon	Mutation	Codon	Mutation	Codon	Mutation	Codon	Mutation
—, Mutation was not detected
COK169 Ca	82×40	Advanced carcinoma	189	GCC→GTC	245	GGC→AGC	1487–8	T deletion	13	GGC→GAC
							1545	TCA→TGA
COK169 P1	12×10×6	Early carcinoma	189	GCC→GTC	—		1378	CAG→TAG	12	GGT→GTT
COK169 P2	11×7×3	Early carcinoma	189	GCC→GTC	—		1449–75	80 bp repeat	—
COK169 P3	6×3×2	Adenoma with severe atypia	189	GCC→GTC	—		1450	CGA→TGA	—
							Loss of the other allele
COK169 P4	3×2×1	Adenoma with severe atypia	189	GCC→GTC	—		1367	CAG→TAG	—
COK169 P5	3×2×1	Adenoma with severe atypia	189	GCC→GTC	—		1464	GAG→TAG	—