Effect of varying concentrations of affinity purified autoantibodies from six different patients with CD to tTG.
| Patients with CD | Fold molar excess of antibody to tTG | |||
|---|---|---|---|---|
| 0.5 | 1 | 2 | 5.5 | |
| *IgA anti-tTG titres as determined by ELISA are shown in parenthesis. The values indicate the percentage of remaining tTG activity compared to basal tTG in the absence of inhibitory antibodies. | ||||
| CD, coeliac disease; tTG, tissue transglutaminase. | ||||
| CD 1 (163)* | – | 59 | 32 | 25 |
| CD 2 (70) | – | 30 | 45 | 22 |
| CD 3 (217) | – | 83 | 50 | 33 |
| CD 4 (100) | – | 70 | 35 | 44 |
| CD 5 (91) | – | 123 | 51 | 42 |
| CD 6 (91) | 123 | 85 | 63 | – |