Relative risks (hazard rates) of relapse according to the multivariate analysis (Cox regression stratified by centre and correcting for sex, HBV DNA, ALT, and race)
| Variable | HBeAg relapse | HBV DNA relapse | ||
|---|---|---|---|---|
| Variable | Relative risk (95% CI) | p Value (log likelihood) | Relative risk (95% CI) | p Value (log likelihood) |
| IFN, interferon; LAM, lamivudine; HBV, hepatitis B virus; ALT, alanine aminotransferase; ULN, upper limit of normal. | ||||
| Therapy | 0.01 | 0.01 | ||
| IFN | 1 | 1 | ||
| LAM | 4.6 (1.4–14.5) | 0.01 | 3.9 (1.3–12.1) | 0.02 |
| Combination | 0.7 (0.1–3.9) | 0.72 | 0.6 (0.1–2.9) | 0.50 |
| Sex | ||||
| Male | 1 | 1 | ||
| Female | 0.4 (0.2–0.9) | 0.04 | 0.5 (0.2–1.2) | 0.12 |
| Race | ||||
| Caucasian | 1 | 1 | ||
| Asian | 0.8 (0.3–2.4) | 0.74 | 1.1 (0.4–3.0) | 0.84 |
| Log HBV DNA | 1.61 (1.03–2.52) | 0.03 | 1.7 (1.1–2.6) | 0.02 |
| ALT (×ULN) | 0.03 | 0.05 | ||
| ≤2 | 1 | 1 | ||
| 2–5 | 0.4 (0.2–0.9) | 0.02 | 0.4 (0.2–0.9) | 0.03 |
| ≥5 | 0.3 (0.1–0.8) | 0.01 | 0.4 (0.2–0.9) | 0.03 |