Stratified transmission disequilibrium test analysis of the IBD5 haplotype, CARD15, and TNF−857 variants in Caucasian Crohn’s disease
| Variant | Phenotype* | T/U‡ | Ratio | p Value |
|---|---|---|---|---|
| *CARD15 (or IBD5 or TNF−857)-0, wild type; -1+2 carrying one or two disease associated variants (for CARD15 any of Arg702Trp, Gly908Arg, Leu1007fsinsC). | ||||
| †Note the common TNF−857C allele is associated with inflammatory bowel disease. | ||||
| ‡Transmitted (T)/untransmitted (U). | ||||
| IBD5 | CD | 162/114 | 1.4 | 0.0066 |
| CD-CARD15-0 | 106/66 | 1.6 | 0.0033 | |
| CD-CARD15-1+2 | 52/45 | 1.2 | 0.55 | |
| CD-TNF857-CT/TT | 15/9 | 1.7 | 0.31 | |
| CD-TNF857-CC | 145/103 | 1.4 | 0.0088 | |
| CARD15 Arg702Trp | CD | 65/37 | 1.8 | 0.0059 |
| CD-IBD5-0 | 17/12 | 1.4 | 0.45 | |
| CD-IBD5-1+2 | 47/24 | 2.0 | 0.0064 | |
| CD-TNF857-CT/TT | 11/4 | 2.8 | 0.12 | |
| CD-TNF857-CC | 53/32 | 1.7 | 0.021 | |
| CARD15 Leu1007fsinsC | CD | 47/9 | 5.2 | <10−5 |
| CD-IBD5-0 | 19/4 | 4.8 | 0.0067 | |
| CD-IBD5-1+2 | 27/5 | 5.4 | 0.00019 | |
| CD-TNF857-CT/TT | 7/0 | 0.016 | ||
| CD-TNF857-CC | 40/9 | 4.4 | <10−4 | |
| TNF−857C† | CD | 40/27 | 1.5 | 0.16 |
| CD-IBD5-0 | 8/11 | 0.7 | 0.61 | |
| CD-IBD5-1+2 | 31/16 | 1.9 | 0.026 | |
| CD-CARD15–0 | 27/12 | 2.3 | 0.030 | |
| CD-CARD15–1+2 | 13/14 | 0.9 | 1.0 | |